Fam65b Phosphorylation Relieves Tonic RhoA Inhibition During T Cell Migration

Fam65b Phosphorylation Relieves Tonic RhoA Inhibition During T Cell Migration

We previously identified Fam65b as an atypical inhibitor of the small G protein RhoA. Using a conditional model of a Fam65b-deficient mouse, we first show that Fam65b restricts spontaneous RhoA activation in resting T lymphocytes and regulates intranodal T cell migration in vivo. We next aimed at un...

Full description

Bibliographic Details
Main Authors: Laura Megrelis, Elyas El Ghoul, Federica Moalli, Margaux Versapuech, Shamir Cassim, Nora Ruef, Jens V. Stein, Marianne Mangeney, Jérôme Delon
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
Rho GTPases
T cell migration
chemokine signaling
mouse model
phosphoproteins
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02001/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02001/full

Similar Items