Tambulin from Zanthoxylum armatum acutely potentiates the glucose-induced insulin secretion via KATP-independent Ca2+-dependent amplifying pathway

Tambulin from Zanthoxylum armatum acutely potentiates the glucose-induced insulin secretion via KATP-independent Ca2+-dependent amplifying pathway

Tambulin, a flavonol isolated from Zanthoxylum armatum, showed potent insulin secretory activity in our preliminary anti-diabetic screening. Here, we explored the insulin secretory mechanism(s) of tambulin focusing in glucose-dependent, KATP ‒ and Ca2+‒channels dependent, and cAMP-PKA pathways. Mice...

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Bibliographic Details
Main Authors: Abdul Hameed, Sayed Ali Raza, M. Israr Khan, Janaki Baral, Achyut Adhikari, Mohammad Nur-e-Alam, Sarfaraz Ahmed, Adnan J. Al-Rehaily, Sajda Ashraf, Zaheer Ul-Haq, Rahman M. Hafizur
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Tambulin
Insulin secretion
Mice islets
cAMP
Ca2+ channel
KATPchannel
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219318402

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http://www.sciencedirect.com/science/article/pii/S0753332219318402

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