Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID

Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID

Infection or chronic inflammation is a risk factor for childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors show that the DNA editing enzyme AID is expressed in infected B cells but using genetic mouse models show that it does not contribute to leukemia pathogenesis.

Bibliographic Details
Main Authors: Guillermo Rodríguez-Hernández, Friederike V. Opitz, Pilar Delgado, Carolin Walter, Ángel F. Álvarez-Prado, Inés González-Herrero, Franziska Auer, Ute Fischer, Stefan Janssen, Christoph Bartenhagen, Javier Raboso-Gallego, Ana Casado-García, Alberto Orfao, Oscar Blanco, Diego Alonso-López, Javier De Las Rivas, Sara González de Tena-Dávila, Markus Müschen, Martin Dugas, Francisco Javier García Criado, María Begoña García Cenador, Carolina Vicente-Dueñas, Julia Hauer, Almudena R. Ramiro, Isidro Sanchez-Garcia, Arndt Borkhardt
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13570-y

Internet

https://doi.org/10.1038/s41467-019-13570-y

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