Oxidative and Proteolytic Inactivation of Alpha-1 Antitrypsin in Bronchopulmonary Dysplasia Pathogenesis: A Top-Down Proteomic Bronchoalveolar Lavage Fluid Analysis

Oxidative and Proteolytic Inactivation of Alpha-1 Antitrypsin in Bronchopulmonary Dysplasia Pathogenesis: A Top-Down Proteomic Bronchoalveolar Lavage Fluid Analysis

The study investigates the role of the oxidative and proteolytic inactivation of alpha-1 antitrypsin (AAT) in the pathogenesis of bronchopulmonary dysplasia (BPD) in premature infants. Bronchoalveolar lavage fluid (BALF) samples were collected on the 3rd day of life from mechanically ventilated neon...

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Bibliographic Details
Main Authors: Chiara Tirone, Federica Iavarone, Milena Tana, Alessandra Lio, Claudia Aurilia, Simonetta Costa, Massimo Castagnola, Irene Messana, Giovanni Vento
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pediatrics
Subjects:
alpha-1 antitrypsin
preterm infants
bronchopulmonary displasia
bronchoalveolar lavage fluid
proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2021.597415/full

Internet

https://www.frontiersin.org/articles/10.3389/fped.2021.597415/full

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