Nras overexpression results in granulocytosis, T-cell expansion and early lethality in mice.

Nras overexpression results in granulocytosis, T-cell expansion and early lethality in mice.

NRAS is a proto-oncogene involved in numerous myeloid malignancies. Here, we report on a mouse line bearing a single retroviral long terminal repeat inserted into Nras. This genetic modification resulted in an increased level of wild type Nras mRNA giving the possibility of studying the function and...

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Bibliographic Details
Main Authors: Louise Berkhoudt Lassen, Borja Ballarín-González, Alexander Schmitz, Annette Füchtbauer, Finn Skou Pedersen, Ernst-Martin Füchtbauer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3410918?pdf=render

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http://europepmc.org/articles/PMC3410918?pdf=render

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