Ab-externo AAV-mediated gene delivery to the suprachoroidal space using a 250 micron flexible microcatheter.

Ab-externo AAV-mediated gene delivery to the suprachoroidal space using a 250 micron flexible microcatheter.

The current method of delivering gene replacement to the posterior segment of the eye involves a three-port pars plana vitrectomy followed by injection of the agent through a 37-gauge cannula, which is potentially wrought with retinal complications. In this paper we investigate the safety and effica...

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Bibliographic Details
Main Authors: Marc C Peden, Jeff Min, Craig Meyers, Zachary Lukowski, Qiuhong Li, Sanford L Boye, Monica Levine, William W Hauswirth, Ramakrishna Ratnakaram, William Dawson, Wesley C Smith, Mark B Sherwood
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3037961?pdf=render

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http://europepmc.org/articles/PMC3037961?pdf=render

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