Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP

Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP

Abstract The multi-domain transcriptional coactivators CBP/p300 integrate a multitude of signaling inputs, interacting with more than 400 proteins via one or more of their globular domains. While CBP/p300 function is typically considered in terms of these structured domains, about half of the protei...

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Bibliographic Details
Main Authors: Sara Contreras-Martos, Alessandro Piai, Simone Kosol, Mihaly Varadi, Angela Bekesi, Pierre Lebrun, Alexander N. Volkov, Kris Gevaert, Roberta Pierattelli, Isabella C. Felli, Peter Tompa
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-04611-x

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https://doi.org/10.1038/s41598-017-04611-x

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