Vulnerable Parkin Loss-of-Function Drosophila Dopaminergic Neurons Have Advanced Mitochondrial Aging, Mitochondrial Network Loss and Transiently Reduced Autophagosome Recruitment

Vulnerable Parkin Loss-of-Function Drosophila Dopaminergic Neurons Have Advanced Mitochondrial Aging, Mitochondrial Network Loss and Transiently Reduced Autophagosome Recruitment

Selective degeneration of substantia nigra dopaminergic (DA) neurons is a hallmark pathology of familial Parkinson’s disease (PD). While the mechanism of degeneration is elusive, abnormalities in mitochondrial function and turnover are strongly implicated. An Autosomal Recessive-Juvenile Parkinsonis...

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Bibliographic Details
Main Authors: Juliana Cackovic, Susana Gutierrez-Luke, Gerald B. Call, Amber Juba, Stephanie O’Brien, Charles H. Jun, Lori M. Buhlman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
parkin
neurodegeneration
dopaminergic neurons
Parkinson’s disease
autophagy
mitochondria
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00039/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2018.00039/full

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