A Super-Enhancer Driven by FOSL1 Controls miR-21-5p Expression in Head and Neck Squamous Cell Carcinoma

A Super-Enhancer Driven by FOSL1 Controls miR-21-5p Expression in Head and Neck Squamous Cell Carcinoma

MiR-21-5p is one of the most common oncogenic miRNAs that is upregulated in many solid cancers by inhibiting its target genes at the posttranscriptional level. However, the upstream regulatory mechanisms of miR-21-5p are still not well documented in cancers. Here, we identify a super-enhancer associ...

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Bibliographic Details
Main Authors: Yuehan Wan, Rosalie G. Hoyle, Nan Xie, Wenjin Wang, Hongshi Cai, Ming Zhang, Zhikun Ma, Gan Xiong, Xiuyun Xu, Zhengxian Huang, Xiqiang Liu, Jiong Li, Cheng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
super enhancer
FOSL1
miR-21-5p
head and neck squamous cell carcinoma
metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.656628/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.656628/full

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