Cycling Stem Cells Are Radioresistant and Regenerate the Intestine

Cycling Stem Cells Are Radioresistant and Regenerate the Intestine

Summary: A certain number of epithelial cells in intestinal crypts are DNA damage resistant and contribute to regeneration. However, the cellular mechanism underlying intestinal regeneration remains unclear. Using lineage tracing, we show that cells marked by an Msi1 reporter (Msi1+) are right above...

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Bibliographic Details
Main Authors: Xiaole Sheng, Ziguang Lin, Cong Lv, Chunlei Shao, Xueyun Bi, Min Deng, Jiuzhi Xu, Christian F. Guerrero-Juarez, Mengzhen Li, Xi Wu, Ran Zhao, Xu Yang, Guilin Li, Xiaowei Liu, Qingyu Wang, Qing Nie, Wei Cui, Shan Gao, Hongquan Zhang, Zhihua Liu, Yingzi Cong, Maksim V. Plikus, Christopher J. Lengner, Bogi Andersen, Fazheng Ren, Zhengquan Yu
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
Msi1
epithelial regeneration
intestinal stem cells
DNA damage response
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309335

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http://www.sciencedirect.com/science/article/pii/S2211124720309335

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