Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro

Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro

Abstract Background Collagen is a structural protein that provides mechanical stability and defined architectures to skin. In collagen-based skin disorders this stability is lost, either due to mutations in collagens or in the chaperones involved in collagen assembly. This leads to chronic wounds, s...

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Bibliographic Details
Main Authors: Essak S. Khan, Shrikrishnan Sankaran, Lorena Llontop, Aránzazu del Campo
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Molecular and Cell Biology
Subjects:
Hsp47
Collagen deposition
Extracellular matrix
Collagen fibrils
Online Access:http://link.springer.com/article/10.1186/s12860-020-00267-0

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http://link.springer.com/article/10.1186/s12860-020-00267-0

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