Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro

Abstract Background Collagen is a structural protein that provides mechanical stability and defined architectures to skin. In collagen-based skin disorders this stability is lost, either due to mutations in collagens or in the chaperones involved in collagen assembly. This leads to chronic wounds, s...

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Bibliographic Details
Main Authors: Essak S. Khan, Shrikrishnan Sankaran, Lorena Llontop, Aránzazu del Campo
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Molecular and Cell Biology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12860-020-00267-0