CLEAR: coverage-based limiting-cell experiment analysis for RNA-seq

CLEAR: coverage-based limiting-cell experiment analysis for RNA-seq

Abstract Background Direct cDNA preamplification protocols developed for single-cell RNA-seq have enabled transcriptome profiling of precious clinical samples and rare cell populations without the need for sample pooling or RNA extraction. We term the use of single-cell chemistries for sequencing lo...

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Bibliographic Details
Main Authors: Logan A. Walker, Michael G. Sovic, Chi-Ling Chiang, Eileen Hu, Jiyeon K. Denninger, Xi Chen, Elizabeth D. Kirby, John C. Byrd, Natarajan Muthusamy, Ralf Bundschuh, Pearlly Yan
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Translational Medicine
Subjects:
Rare cells
Ultralow input
Pre-filtering
RNA-seq
Differential gene expression analysis
Online Access:https://doi.org/10.1186/s12967-020-02247-6

Internet

https://doi.org/10.1186/s12967-020-02247-6

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