Relative proteome quantification of alpha, beta, gamma and delta globin chains in early eluting peaks of Bio-Rad variant II® CE-HPLC of hemoglobin from healthy and beta-thalassemia subjects in Malaysia

This is the first report of QQQ-mass spectrometric identification and quantification of the Hb subunits, alpha, beta, delta and gamma globin peptides, derived from enzymatic-digestion of proteins in the early unknown peaks of the Bio-Rad cation-exchange chromatography of haemoglobin. The objectives...

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Bibliographic Details
Main Authors: Uday Younis Hussein Abdullah, Hishamshah M. Ibrahim, Haitham Muhammed Jassim, Mohamad Zaki Salleh, Teh Lay Kek, Mohd Nur Fakhruzzaman bin Noorizhab, Bin Alwi Zilfalil, Prapin Wilairat, Suthat Fucharoen
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Biochemistry and Biophysics Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580819300482