β-Thujaplicin Enhances TRAIL-Induced Apoptosis via the Dual Effects of XIAP Inhibition and Degradation in NCI-H460 Human Lung Cancer Cells

<b>Background</b>: β-thujaplicin, a natural tropolone derivative, has anticancer effects on various cancer cells via apoptosis. However, the apoptosis regulatory proteins involved in this process have yet to be revealed. <b>Methods:</b> Trypan blue staining, a WST-8 assay, an...

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Bibliographic Details
Main Authors: Saki Seno, Minori Kimura, Yuki Yashiro, Ryutaro Kimura, Kanae Adachi, Aoi Terabayashi, Mio Takahashi, Takahiro Oyama, Hideaki Abe, Takehiko Abe, Sei-ichi Tanuma, Ryoko Takasawa
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Medicines
Subjects:
Online Access:https://www.mdpi.com/2305-6320/8/6/26