Effects of Strontium-Doped β-Tricalcium Scaffold on Longitudinal Nuclear Factor-Kappa Beta and Vascular Endothelial Growth Factor Receptor-2 Promoter Activities during Healing in a Murine Critical-Size Bone Defect Model

Effects of Strontium-Doped β-Tricalcium Scaffold on Longitudinal Nuclear Factor-Kappa Beta and Vascular Endothelial Growth Factor Receptor-2 Promoter Activities during Healing in a Murine Critical-Size Bone Defect Model

It was hypothesized that strontium (Sr)-doped β-tricalcium phosphate (TCP)-based scaffolds have a positive effect on the regeneration of large bone defects (LBD). Readouts in our mice models were nuclear factor-kappa beta (NF-κB) activity and vascular endothelial growth factor receptor-2 (VEGFR-2) p...

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Bibliographic Details
Main Authors: Mersedeh Tohidnezhad, Yusuke Kubo, Philipp Lichte, Tobias Heigl, Diana Roch, Nazanin Barahmand Pour, Christian Bergmann, Tolga Taha Sönmez, Jennifer Vanessa Phi Hock, Athanassios Fragoulis, Felix Gremse, Stefanie Rosenhain, Alexander Slowik, Michaela Bienert, Nisreen Kweider, Christoph Jan Wruck, Holger Jahr, Frank Hildebrand, Hans Christoph Pape, Sabine Neuß, Horst Fischer, Thomas Pufe
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
large bone defects
β-tricalcium phosphate
strontium
NF-κB
VEGFR-2
bioluminescence
Online Access:https://www.mdpi.com/1422-0067/21/9/3208

Internet

https://www.mdpi.com/1422-0067/21/9/3208

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