The IL1β-IL1R signaling is involved in the stimulatory effects triggered by hypoxia in breast cancer cells and cancer-associated fibroblasts (CAFs)

The IL1β-IL1R signaling is involved in the stimulatory effects triggered by hypoxia in breast cancer cells and cancer-associated fibroblasts (CAFs)

Abstract Background Hypoxia plays a relevant role in tumor-related inflammation toward the metastatic spread and cancer aggressiveness. The pro-inflammatory cytokine interleukin-1β (IL-β) and its cognate receptor IL1R1 contribute to the initiation and progression of breast cancer determining pro-tum...

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Bibliographic Details
Main Authors: Rosamaria Lappano, Marianna Talia, Francesca Cirillo, Damiano Cosimo Rigiracciolo, Domenica Scordamaglia, Rita Guzzi, Anna Maria Miglietta, Ernestina Marianna De Francesco, Antonino Belfiore, Andrew H. Sims, Marcello Maggiolini
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hypoxia
Hypoxia inducible factor-1α (HIF-1α)
Interleukin-1β (IL-β)
G protein estrogen receptor (GPER)
Breast cancer
Cancer-associated fibroblasts (CAFs)
Online Access:http://link.springer.com/article/10.1186/s13046-020-01667-y

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http://link.springer.com/article/10.1186/s13046-020-01667-y

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