Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE

Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE

For more than a century, diabetic patients have been considered immunosuppressed due to defects in phagocytosis and microbial killing. We confirmed that diabetic mice were hypersusceptible to bacteremia caused by Gram-negative bacteria (GNB), dying at inocula nonlethal to nondiabetic mice. Contrary...

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Bibliographic Details
Main Authors: Travis B. Nielsen, Paul Pantapalangkoor, Jun Yan, Brian M. Luna, Ken Dekitani, Kevin Bruhn, Brandon Tan, Justin Junus, Robert A. Bonomo, Ann Marie Schmidt, Michael Everson, Frederick Duncanson, Terence M. Doherty, Lin Lin, Brad Spellberg, Paul Dunman
Format: Article
Language:English
Published: American Society for Microbiology 2017-08-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/8/4/e00818-17

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http://mbio.asm.org/cgi/content/full/8/4/e00818-17

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