Dose-dependent effect of N′-Nitrosodiethylamine on hepatic architecture, RBC rheology and polypeptide repertoire in Wistar rats

Dose-dependent effect of N′-Nitrosodiethylamine on hepatic architecture, RBC rheology and polypeptide repertoire in Wistar rats

N′-Nitrosodiethylamine (NDEA) is an effective hepatotoxicant, carcinogen and mutagen. NDEA-induced hepatic necrosis, through metabolic activation by CYP2E1, is an extensively used experimental model. In the present study, we analysed the dose- and time-dependent effect of NDEA on hepatic damage, RBC...

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Bibliographic Details
Main Authors: Mukherjee Devoshree, Ahmad Riaz
Format: Article
Language:English
Published: Sciendo 2015-03-01
Series:Interdisciplinary Toxicology
Subjects:
hepatotoxicity
n′-nitrosodiethylamine
oxidative stress
polypeptide repertoire
rbc
sds-page
Online Access:https://doi.org/10.1515/intox-2015-0001

Internet

https://doi.org/10.1515/intox-2015-0001

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