Formation of trans-activation competent HIV-1 Rev:RRE complexes requires the recruitment of multiple protein activation domains.

Formation of trans-activation competent HIV-1 Rev:RRE complexes requires the recruitment of multiple protein activation domains.

The HIV-1 Rev trans-activator is a nucleocytoplasmic shuttle protein that is essential for virus replication. Rev directly binds to unspliced and incompletely spliced viral RNA via the cis-acting Rev Response Element (RRE) sequence. Subsequently, Rev oligomerizes cooperatively and interacts with the...

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Bibliographic Details
Main Authors: Dirk Hoffmann, Doreen Schwarck, Carina Banning, Matthias Brenner, Lakshmikanth Mariyanna, Marcel Krepstakies, Michael Schindler, David P Millar, Joachim Hauber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3366918?pdf=render

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http://europepmc.org/articles/PMC3366918?pdf=render

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