Exploring the anti-cancer activity of novel thiosemicarbazones generated through the combination of retro-fragments: dissection of critical structure-activity relationships.

Exploring the anti-cancer activity of novel thiosemicarbazones generated through the combination of retro-fragments: dissection of critical structure-activity relationships.

Thiosemicarbazones (TSCs) are an interesting class of ligands that show a diverse range of biological activity, including anti-fungal, anti-viral and anti-cancer effects. Our previous studies have demonstrated the potent in vivo anti-tumor activity of novel TSCs and their ability to overcome resista...

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Bibliographic Details
Main Authors: Maciej Serda, Danuta S Kalinowski, Nathalie Rasko, Eliška Potůčková, Anna Mrozek-Wilczkiewicz, Robert Musiol, Jan G Małecki, Mieczysław Sajewicz, Alicja Ratuszna, Angelika Muchowicz, Jakub Gołąb, Tomáš Simůnek, Des R Richardson, Jaroslaw Polanski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0110291

Internet

https://doi.org/10.1371/journal.pone.0110291

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