Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells

Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells

BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal to its ED50 at 72 h (117 μM). Exposure of cells...

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Bibliographic Details
Main Authors: Alessandra Longo, Mariangela Librizzi, Irina S. Chuckowree, Christine B. Baltus, John Spencer, Claudio Luparello
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Molecules
Subjects:
boronic acid
BC-11
plasminogen activator inhibitor
breast cancer
cytotoxicity
MDA-MB231 cells
Online Access:http://www.mdpi.com/1420-3049/20/6/9879

Internet

http://www.mdpi.com/1420-3049/20/6/9879

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