Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations

Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations

Abstract Background About 11% of all human genetic diseases are caused by nonsense mutations that generate premature translation termination codons (PTCs) in messenger RNAs (mRNA). PTCs not only lead to the production of truncated proteins, but also often result in  decreased mRNA abundance due to ...

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Bibliographic Details
Main Authors: Lulu Huang, Audrey Low, Sagar S. Damle, Melissa M. Keenan, Steven Kuntz, Susan F. Murray, Brett P. Monia, Shuling Guo
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Genome Biology
Subjects:
NMD
PTC
ASO
Upf3b
RNA
Hemophilia
Online Access:http://link.springer.com/article/10.1186/s13059-017-1386-9

Internet

http://link.springer.com/article/10.1186/s13059-017-1386-9

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