Protein targets of thiazolidinone derivatives in Toxoplasma gondii and insights into their binding to ROP18

Protein targets of thiazolidinone derivatives in Toxoplasma gondii and insights into their binding to ROP18

Abstract Background Thiazolidinone derivatives show inhibitory activity (IC50) against the Toxoplasma gondii parasite, as well as high selectivity with high therapeutic index. To disclose the target proteins of the thiazolidinone core in this parasite, we explored in silico the active sites of diffe...

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Bibliographic Details
Main Authors: Diego Molina, Rodrigo Cossio-Pérez, Cristian Rocha-Roa, Lina Pedraza, Edwar Cortes, Alejandro Hernández, Jorge E. Gómez-Marín
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Genomics
Subjects:
Toxoplasma gondii
Thiazolidinone
Rhoptry proteins
Online Access:http://link.springer.com/article/10.1186/s12864-018-5223-7

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http://link.springer.com/article/10.1186/s12864-018-5223-7

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