Dysregulation of IL-17/IL-22 Effector Functions in Blood and Gut Mucosal Gamma Delta T Cells Correlates With Increase in Circulating Leaky Gut and Inflammatory Markers During cART-Treated Chronic SIV Infection in Macaques

Dysregulation of IL-17/IL-22 Effector Functions in Blood and Gut Mucosal Gamma Delta T Cells Correlates With Increase in Circulating Leaky Gut and Inflammatory Markers During cART-Treated Chronic SIV Infection in Macaques

HIV-associated inflammation has been implicated in the premature aging and increased risk of age-associated comorbidities in cART-treated individuals. However, the immune mechanisms underlying the chronic inflammatory state of cART-suppressed HIV infection remain unclear. Here, we investigated the r...

Full description

Bibliographic Details
Main Authors: Edith M. Walker, Nadia Slisarenko, Giovanni L. Gerrets, Brooke F. Grasperge, Julie A. Mattison, Patricia J. Kissinger, David A. Welsh, Ronald S. Veazey, S. Michal Jazwinski, Namita Rout
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
SIV
intestinal epithelial barrier disruption
IFABP
LBP
sCD14
gammadelta T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.647398/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.647398/full

Similar Items