HIV Nef enhances the expression of oncogenic c-MYC and activation-induced cytidine deaminase in Burkitt lymphoma cells, promoting genomic instability

HIV Nef enhances the expression of oncogenic c-MYC and activation-induced cytidine deaminase in Burkitt lymphoma cells, promoting genomic instability

Abstract Background Non-Hodgkin lymphoma is of high prevalence among HIV-infected people. In particular, the incidence of HIV-associated Burkitt lymphoma (BL) remains high despite the advent of Highly Active Anti-Retroviral Therapy. Recent evidence shows that serum-soluble HIV proteins can enhance o...

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Bibliographic Details
Main Authors: Nontlantla Mdletshe, Andrew Nel, Karen Shires, Shaheen Mowla
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Infectious Agents and Cancer
Subjects:
HIV
Nef
Burkitt lymphoma
c-MYC
AID
Genome integrity
Online Access:http://link.springer.com/article/10.1186/s13027-020-00320-9

Internet

http://link.springer.com/article/10.1186/s13027-020-00320-9

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