Longitudinal structural cerebral changes related to core CSF biomarkers in preclinical Alzheimer's disease: A study of two independent datasets

Alzheimer's disease (AD) is characterized by an accumulation of β-amyloid (Aβ42) accompanied by brain atrophy and cognitive decline. Several recent studies have shown that Aβ42 accumulation is associated with gray matter (GM) changes prior to the development of cognitive impairment, in the so-c...

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Bibliographic Details
Main Authors: Carles Falcon, Alan Tucholka, Gemma C. Monté-Rubio, Raffaele Cacciaglia, Grégory Operto, Lorena Rami, Juan Domingo Gispert, José Luis Molinuevo
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:NeuroImage: Clinical
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158218301256