Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats

Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats

Abstract Background Our previous study indicated that hypoxic preconditioning reduced receptor interacting protein (RIP) 3-mediated necroptotic neuronal death in hippocampal CA1 of adult rats after transient global cerebral ischemia (tGCI). Although mixed lineage kinase domain-like (MLKL) has emerge...

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Bibliographic Details
Main Authors: Lixuan Zhan, Xiaomei Lu, Wensheng Xu, Weiwen Sun, En Xu
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Neuroinflammation
Subjects:
Necroptosis
MLKL
IL-1R1
Plasma membrane translocation
Calcium ion influx
Cerebral ischemia
Online Access:https://doi.org/10.1186/s12974-021-02141-y

Internet

https://doi.org/10.1186/s12974-021-02141-y

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