Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt

Osteoclasts are giant bone cells formed by fusion from monocytes and uniquely capable of a complete destruction of mineralized tissues. Previously, we have demonstrated that in energy-rich environment not only osteoclast fusion index (the number of nuclei each osteoclast contains), but also cytoplas...

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Bibliographic Details
Main Authors: Kerstin Tiedemann, Damien Le Nihouannen, Jenna E. Fong, Osama Hussein, Jake E. Barralet, Svetlana V. Komarova
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
osteoclast
monocyte fusion
cell growth
mTOR
Akt
Online Access:http://journal.frontiersin.org/article/10.3389/fcell.2017.00054/full

Internet

http://journal.frontiersin.org/article/10.3389/fcell.2017.00054/full

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