Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis

Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis

Pro- and anti-inflammatory effector functions of IgG antibodies (Abs) depend on their subclass and Fc glycosylation pattern. Accumulation of non-galactosylated (agalactosylated; G0) IgG Abs in the serum of rheumatoid arthritis and systemic lupus erythematosus (SLE) patients reflects severity of the...

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Bibliographic Details
Main Authors: Yannic C. Bartsch, Johann Rahmöller, Maria M. M. Mertes, Susanne Eiglmeier, Felix K. M. Lorenz, Alexander D. Stoehr, Dominique Braumann, Alexandra K. Lorenz, André Winkler, Gina-Maria Lilienthal, Janina Petry, Juliane Hobusch, Moritz Steinhaus, Constanze Hess, Vivien Holecska, Carolin T. Schoen, Carolin M. Oefner, Alexei Leliavski, Véronique Blanchard, Marc Ehlers
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
IgG glycosylation
sialylation
ST6gal1
systemic lupus erythematosus
rheumatoid arthritis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01183/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01183/full

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