Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease

Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease

<p>Abstract</p> <p>Background</p> <p>Chronic neuroinflammation is an important component of Alzheimer’s disease and could contribute to neuronal dysfunction, injury and loss that lead to disease progression. Multiple clinical studies implicate tumor necrosis factor-α as...

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Bibliographic Details
Main Authors: Gabbita S, Srivastava Minu K, Eslami Pirooz, Johnson Ming F, Kobritz Naomi K, Tweedie David, Greig Nigel H, Zemlan Frank P, Sharma Sherven P, Harris-White Marni E
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
memory
neuroinflammation
thalidomide
thiothalidomide
tumor necrosis factor-alpha
Online Access:http://www.jneuroinflammation.com/content/9/1/99

Internet

http://www.jneuroinflammation.com/content/9/1/99

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