Virus-Like Particles Are a Superior Platform for Presenting M2e Epitopes to Prime Humoral and Cellular Immunity against Influenza Virus

Virus-Like Particles Are a Superior Platform for Presenting M2e Epitopes to Prime Humoral and Cellular Immunity against Influenza Virus

Influenza virus M2 protein has a highly conserved ectodomain (M2e) as a cross-protective antigenic target. We investigated the antigenic and immunogenic properties of tandem repeat M2e (5xM2e) proteins and virus-like particles (5xM2e VLP) to better understand how VLP and protein platform vaccines in...

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Bibliographic Details
Main Authors: Ki-Hye Kim, Young-Man Kwon, Young-Tae Lee, Min-Chul Kim, Hye Suk Hwang, Eun-Ju Ko, Youri Lee, Hyo-Jick Choi, Sang-Moo Kang
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Vaccines
Subjects:
priming effect
5xM2e epitopes
virus-like particles (VLP), cross-protection
innate/adaptive immunity
Online Access:http://www.mdpi.com/2076-393X/6/4/66

Internet

http://www.mdpi.com/2076-393X/6/4/66

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