Transcriptional profiling of human dendritic cell populations and models--unique profiles of in vitro dendritic cells and implications on functionality and applicability.

BACKGROUND: Dendritic cells (DCs) comprise heterogeneous populations of cells, which act as central orchestrators of the immune response. Applicability of primary DCs is restricted due to their scarcity and therefore DC models are commonly employed in DC-based immunotherapy strategies and in vitro t...

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Bibliographic Details
Main Authors: Kristina Lundberg, Ann-Sofie Albrekt, Inge Nelissen, Saskia Santegoets, Tanja D de Gruijl, Sue Gibbs, Malin Lindstedt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3544800?pdf=render