Aged human mesenchymal stem cells: the duration of bone morphogenetic protein-2 stimulation determines induction or inhibition of osteogenic differentiation

Bone morphogenetic protein 2 (BMP-2) is a potent osteoinductive cytokine and a growing number of i<em>n vitro</em> studies analyze its effects on human mesenchymal stem cells (hMSC) derived from aged or osteoporotic donors. In these studies the exact quantification of osteogenic differen...

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Bibliographic Details
Main Authors: Jostein Heggebö, Florian Haasters, Hans Polzer, Christina Schwarz, Maximilian Michael Saller, Wolf Mutschler, Matthias Schieker, Wolf Christian Prall
Format: Article
Language:English
Published: Open Medical Publishing 2014-06-01
Series:Orthopedic Reviews
Subjects:
Online Access:http://www.pagepress.org/journals/index.php/or/article/view/5242