A directed molecular evolution approach to improved immunogenicity of the HIV-1 envelope glycoprotein.

A directed molecular evolution approach to improved immunogenicity of the HIV-1 envelope glycoprotein.

A prophylactic vaccine is needed to slow the spread of HIV-1 infection. Optimization of the wild-type envelope glycoproteins to create immunogens that can elicit effective neutralizing antibodies is a high priority. Starting with ten genes encoding subtype B HIV-1 gp120 envelope glycoproteins and us...

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Bibliographic Details
Main Authors: Sean X Du, Li Xu, Wenge Zhang, Susan Tang, Rebecca I Boenig, Helen Chen, Ellaine B Mariano, Michael B Zwick, Paul W H I Parren, Dennis R Burton, Terri Wrin, Christos J Petropoulos, John A Ballantyne, Michael Chambers, Robert G Whalen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3126809?pdf=render

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http://europepmc.org/articles/PMC3126809?pdf=render

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