Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux

Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux

Energy production is inevitably linked to the generation of toxic metabolites, such as reactive oxygen and carbonyl species, known as major contributors to ageing and degenerative diseases. It remains unclear how cells can adapt to elevated energy flux accompanied by accumulating harmful by-products...

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Bibliographic Details
Main Authors: Johanna Zemva, Christoph Andreas Fink, Thomas Henry Fleming, Leonard Schmidt, Anne Loft, Stephan Herzig, Robert André Knieß, Matthias Mayer, Bernd Bukau, Peter Paul Nawroth, Jens Tyedmers
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Redox Biology
Subjects:
Methylglyoxal
Reactive metabolites
Glucose metabolism
Nutrient signalling
Protein quality control system
Heat shock proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717305165

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http://www.sciencedirect.com/science/article/pii/S2213231717305165

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