A rapid and sensitive liquid chromatography–tandem mass spectrometric method for the determination of hederasaponin B in rat plasma: Application to a pharmacokinetic study

A rapid and sensitive liquid chromatography–tandem mass spectrometric method for the determination of hederasaponin B in rat plasma: Application to a pharmacokinetic study

A rapid, simple and sensitive ultra-high performance liquid chromatography–tandem mass spectrometric (UPLC–MS/MS) method was developed and validated for the determination of hederasaponin B, an active triterpenoid saponin widely existed in Hedera helix L. Plasma samples were processed by protein pre...

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Bibliographic Details
Main Authors: Jiaxin Liu, Xueyan Yang, Lin Li, Qili Zhang, Zhaoyan Zhang, Xin Zhang, Yunli Zhao, Miao Yu, Zhiguo Yu
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Hederasaponin B
UPLC–MS/MS
Pharmacokinetics
Rat plasma
Double-peak phenomenon
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087616300873

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http://www.sciencedirect.com/science/article/pii/S1818087616300873

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