Brain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study

Abstract Higher cortisol levels due to a hyperactive hypothalamic–pituitary–adrenal axis have been reported in patients with major depressive disorder (MDD). Increased cortisol levels change both the brain morphology and function in MDD patients. The multivariate source-based morphometry (SBM) techn...

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Bibliographic Details
Main Authors: LeHoa Nguyen, Shingo Kakeda, Keita Watanabe, Asuka Katsuki, Koichiro Sugimoto, Natsuki Igata, Takahiro Shinkai, Osamu Abe, Yukunori Korogi, Atsuko Ikenouchi, Reiji Yoshimura
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79220-2