Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications

Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications

Shiga toxins (Stxs) produced by Shiga toxin-producing bacteria Shigella dysenteriae serotype 1 and select serotypes of Escherichia coli are primary virulence factors in the pathogenesis of hemorrhagic colitis progressing to potentially fatal systemic complications, such as hemolytic uremic syndrome...

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Bibliographic Details
Main Authors: Moo-Seung Lee, Sunwoo Koo, Dae Gwin Jeong, Vernon L. Tesh
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:Toxins
Subjects:
Shiga toxins
Shiga toxin type 1 and 2
Shiga toxin-producing Escherichia coli
hemolytic uremic syndrome
signaling pathways
cancer therapeutics
Online Access:http://www.mdpi.com/2072-6651/8/3/77

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http://www.mdpi.com/2072-6651/8/3/77

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