Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impairment in MPTP-Induced Parkinson’s Disease Model

Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impairment in MPTP-Induced Parkinson’s Disease Model

The NLR family pyrin domain containing 3 (NLRP3) inflammasome was reported to be regulated by autophagy and activated during inflammatory procession of Parkinson’s disease (PD). Berberine (BBR) is well-studied to play an important role in promoting anti-inflammatory response to mediate the autophagy...

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Bibliographic Details
Main Authors: Shuxuan Huang, Hanqun Liu, Yuwan Lin, Muchang Liu, Yanhua Li, Hengxu Mao, Zhiling Zhang, Yunlong Zhang, Panghai Ye, Liuyan Ding, Ziting Zhu, Xinling Yang, Chaojun Chen, Xiaoqin Zhu, Xiaoyun Huang, Wenyuan Guo, Pingyi Xu, Lin Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
Parkinson’s disease
NLRP3
neuroinflammation
autophagy
berberine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.618787/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.618787/full

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