ent-Kaurane diterpenoids induce apoptosis and ferroptosis through targeting redox resetting to overcome cisplatin resistance

ent-Kaurane diterpenoids induce apoptosis and ferroptosis through targeting redox resetting to overcome cisplatin resistance

Reactive oxygen species (ROS) induction is an effective mechanism to kill cancer cells for many chemotherapeutics, while resettled redox homeostasis induced by the anticancer drugs will promote cancer chemoresistance. Natural ent-kaurane diterpenoids have been found to bind glutathione (GSH) and sul...

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Bibliographic Details
Main Authors: Yong Sun, Yanan Qiao, Yue Liu, Jinchuan Zhou, Xue Wang, Hongbo Zheng, Zejun Xu, Jiaozhen Zhang, Yi Zhou, Lilin Qian, Chunyang Zhang, Hongxiang Lou
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Redox Biology
Subjects:
ent-kaurane diterpenoids
Cancer resistance
Apoptosis
Ferroptosis
Prdx I/II
GSH
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721001257

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http://www.sciencedirect.com/science/article/pii/S2213231721001257

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