Methylene Blue Preserves Cytochrome Oxidase Activity and Prevents Neurodegeneration and Memory Impairment in Rats With Chronic Cerebral Hypoperfusion

Methylene Blue Preserves Cytochrome Oxidase Activity and Prevents Neurodegeneration and Memory Impairment in Rats With Chronic Cerebral Hypoperfusion

Chronic cerebral hypoperfusion in neurocognitive disorders diminishes cytochrome oxidase activity leading to neurodegenerative effects and impairment of learning and memory. Methylene blue at low doses stimulates cytochrome oxidase activity and may thus counteract the adverse effects of cerebral hyp...

Full description

Bibliographic Details
Main Authors: Allison M. Auchter, Douglas W. Barrett, Marie H. Monfils, F. Gonzalez-Lima
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
methylene blue
chronic cerebral hypoperfusion
carotid artery occlusion
cytochrome oxidase
interregional correlations
vascular hypothesis of Alzheimer’s dementia
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00130/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00130/full

Similar Items