G ATA2 mediates the negative regulation of the prepro-thyrotropin-releasing hormone gene by liganded T3 receptor β2 in the rat hypothalamic paraventricular nucleus.

G ATA2 mediates the negative regulation of the prepro-thyrotropin-releasing hormone gene by liganded T3 receptor β2 in the rat hypothalamic paraventricular nucleus.

Thyroid hormone (T3) inhibits thyrotropin-releasing hormone (TRH) synthesis in the hypothalamic paraventricular nucleus (PVN). Although the T3 receptor (TR) β2 is known to mediate the negative regulation of the prepro-TRH gene, its molecular mechanism remains unknown. Our previous studies on the T3-...

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Bibliographic Details
Main Authors: Go Kuroda, Shigekazu Sasaki, Akio Matsushita, Kenji Ohba, Yuki Sakai, Shinsuke Shinkai, Hiroko Misawa Nakamura, Satoru Yamagishi, Kohji Sato, Naoko Hirahara, Yutaka Oki, Masahiko Ito, Tetsuro Suzuki, Takafumi Suda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0242380

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https://doi.org/10.1371/journal.pone.0242380

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