Minicircle DNA vector expressing interferon-lambda-3 inhibits hepatitis B virus replication and expression in hepatocyte-derived cell line

Minicircle DNA vector expressing interferon-lambda-3 inhibits hepatitis B virus replication and expression in hepatocyte-derived cell line

Abstract Background Interferon-alpha (IFNα) is a first-line treatment option for chronic hepatitis B virus (HBV) infection, but the severe systemic side-effects limited its clinical application. Interferon-lambda (IFNλ) with comparable antiviral activity and less toxic side-effects is thought to be...

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Bibliographic Details
Main Authors: Xiaoyan Guo, Dianke Chen, Qingxian Cai, Zhanlian Huang, Wenxiong Xu, Liang Peng, Ping Chen
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Molecular and Cell Biology
Subjects:
Minicircle DNA
Type III interferon
Interferon-stimulated gene
Hepatitis B virus
Online Access:http://link.springer.com/article/10.1186/s12860-020-00250-9

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http://link.springer.com/article/10.1186/s12860-020-00250-9

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