Pathogenic effects of inhibition of mTORC1/STAT3 axis facilitates Staphylococcus aureus-induced pyroptosis in human macrophages

Pathogenic effects of inhibition of mTORC1/STAT3 axis facilitates Staphylococcus aureus-induced pyroptosis in human macrophages

Abstract Background Pyroptosis is a recently identified pathway of caspase-mediated cell death in response to microbes, lipopolysaccharide, or chemotherapy in certain types of cells. However, the mechanism of how pyroptosis is regulated is not well-established. Methods Herein, the intracellular bact...

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Bibliographic Details
Main Authors: Ruiyuan Yao, Yuhao Chen, Huifang Hao, Zhixin Guo, Xiaoou Cheng, Yuze Ma, Qiang Ji, Xiaoru Yang, Yanfeng Wang, Xihe Li, Zhigang Wang
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Cell Communication and Signaling
Subjects:
Pyroptosis
Staphylococcus aureus
mTORC1
STAT3
Online Access:https://doi.org/10.1186/s12964-020-00677-9

Internet

https://doi.org/10.1186/s12964-020-00677-9

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