The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier

As researchers across the globe have focused their attention on understanding SARS-CoV-2, the picture that is emerging is that of a virus that has serious effects on the vasculature in multiple organ systems including the cerebral vasculature. Observed effects on the central nervous system include n...

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Bibliographic Details
Main Authors: Tetyana P. Buzhdygan, Brandon J. DeOre, Abigail Baldwin-Leclair, Trent A. Bullock, Hannah M. McGary, Jana A. Khan, Roshanak Razmpour, Jonathan F. Hale, Peter A. Galie, Raghava Potula, Allison M. Andrews, Servio H. Ramirez
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Neurobiology of Disease
Subjects:
COVID-19
SARS-CoV-2
Cerebral vascular biology
Blood-brain barrier
Neuroinflammation
Microfluidic chip
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612030406X

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http://www.sciencedirect.com/science/article/pii/S096999612030406X

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