NF-κB-Chromatin Interactions Drive Diverse Phenotypes by Modulating Transcriptional Noise

NF-κB-Chromatin Interactions Drive Diverse Phenotypes by Modulating Transcriptional Noise

Noisy gene expression generates diverse phenotypes, but little is known about mechanisms that modulate noise. Combining experiments and modeling, we studied how tumor necrosis factor (TNF) initiates noisy expression of latent HIV via the transcription factor nuclear factor κB (NF-κB) and how the HIV...

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Bibliographic Details
Main Authors: Victor C. Wong, Victor L. Bass, M. Elise Bullock, Arvind K. Chavali, Robin E.C. Lee, Walther Mothes, Suzanne Gaudet, Kathryn Miller-Jensen
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
gene expression noise
transcriptional bursting
NF-κB signaling
HIV latency
chromatin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717319174

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http://www.sciencedirect.com/science/article/pii/S2211124717319174

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