Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis.

Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis.

The balance between T helper (Th) 1 and Th2 cell responses is a major determinant of the outcome of experimental leishmaniasis, but polarized Th1 or Th2 responses are not sufficient to account for healing or nonhealing. Here we show that high arginase activity, a hallmark of nonhealing disease, is p...

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Bibliographic Details
Main Authors: Manuel Modolell, Beak-San Choi, Robert O Ryan, Maggie Hancock, Richard G Titus, Tamrat Abebe, Asrat Hailu, Ingrid Müller, Matthew E Rogers, Charles R M Bangham, Markus Munder, Pascale Kropf
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-07-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC2703824?pdf=render

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http://europepmc.org/articles/PMC2703824?pdf=render

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