Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli

Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli

While specific mutations allow organisms to adapt to stressful environments, most changes in an organism's DNA negatively impact fitness. The mutation rate is therefore strictly regulated and often considered a slowly-evolving parameter. In contrast, we demonstrate an unexpected flexibility in...

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Bibliographic Details
Main Authors: Toon Swings, Bram Van den Bergh, Sander Wuyts, Eline Oeyen, Karin Voordeckers, Kevin J Verstrepen, Maarten Fauvart, Natalie Verstraeten, Jan Michiels
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
mutagenesis
evolvability
hypermutation
experimental evolution
ethanol
mortality
Online Access:https://elifesciences.org/articles/22939

Internet

https://elifesciences.org/articles/22939

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