Biological Evaluation of Double Point Modified Analogues of 1,25-Dihydroxyvitamin D2 as Potential Anti-Leukemic Agents

Biological Evaluation of Double Point Modified Analogues of 1,25-Dihydroxyvitamin D2 as Potential Anti-Leukemic Agents

Structurally similar double-point modified analogues of 1,25-dihydroxyvitamin D2 (1,25D2) were screened in vitro for their pro-differentiating activity against the promyeloid cell line HL60. Their affinities towards human full length vitamin D receptor (VDR) and metabolic stability against human vit...

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Bibliographic Details
Main Authors: Aoife Corcoran, Sharmin Nadkarni, Kaori Yasuda, Toshiyuki Sakaki, Geoffrey Brown, Andrzej Kutner, Ewa Marcinkowska
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:International Journal of Molecular Sciences
Subjects:
vitamin D analogues
leukemia
receptor
Online Access:http://www.mdpi.com/1422-0067/17/2/91

Internet

http://www.mdpi.com/1422-0067/17/2/91

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