Sustained intra-articular delivery of IL-1Ra from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis

Sustained intra-articular delivery of IL-1Ra from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis

Post-traumatic arthritis (PTA) is a rapidly progressive form of arthritis that develops due to joint injury, including articular fracture. Current treatments are limited to surgical restoration and stabilization of the joint; however, evidence suggests that PTA progression is mediated by the upregul...

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Bibliographic Details
Main Authors: KA Kimmerling, BD Furman, DS Mangiapani, MA Moverman, SM Sinclair, JL Huebner, A Chilkoti, VB Kraus, LA Setton, F Guilak, SA Olson
Format: Article
Language:English
Published: AO Research Institute Davos 2015-01-01
Series:European Cells & Materials
Subjects:
Arthritis
murine model
cartilage
drug delivery
inflammation
Online Access:http://www.ecmjournal.org/journal/papers/vol029/pdf/v029a10.pdf

Internet

http://www.ecmjournal.org/journal/papers/vol029/pdf/v029a10.pdf

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